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Prescribing Information and Adverse Event Reporting (links to external website):

THINK BEYOND LDL-C TARGETS WITH PROVEN CV RISK REDUCTION

When statins and ezetimibe are not enough, prescribe NILEMDO® (bempedoic acid) or switch ezetimibe to NUSTENDI® (bempedoic acid and ezetimibe) to help your eligible patients reduce their CV risk.1–3
Concomitant use of NILEMDO®/NUSTENDI® with simvastatin >40 mg daily is contraindicated; please refer to the relevant SmPC for more information.1,2

*For study results with respect to effects on LDL-C, CV events and populations studied see section 5.1 of the relevant SmPC.1,2

CV risk reduction estimation for ezetimibe in primary prevention patients has not been established. Evidence for the use of NUSTENDI® in patients at high risk of ASCVD is only available for the lipid-lowering effect (see section 5.1 of the NUSTENDI® SmPC).2

Concomitant use with simvastatin >40 mg daily is contraindicated; please refer to the SmPC for more information.2

Pill
Bempedoic acid 180 mg/ ezetimibe 10 mg fixed dose for all eligible patients2
Once daily
Oral, once daily, with or without food2
Health plus
Can be initiated in your eligible primary and secondary prevention patients2,4

For patients taking a bile acid sequestrant concomitantly, dosing of NUSTENDI® should occur either at least 2 hours before or at least 4 hours after administration of a bile acid sequestrant.2

Liver function tests should be performed at initiation of NUSTENDI® therapy and treatment with NUSTENDI® should be discontinued if an increase in transaminases >3x ULN persists.2

Please refer to the NUSTENDI® SmPC prior to prescribing.2

Concomitant use with simvastatin >40 mg daily is contraindicated; please refer to the SmPC for more information.1

Pill
Bempedoic acid 180 mg for all eligible patients1
Once daily
Oral, once daily, with or without food1
Health plus
Can be initiated in your eligible primary and secondary prevention patients1

Liver function tests should be performed at initiation of NILEMDO® therapy and treatment with NILEMDO® should be discontinued if an increase in transaminases >3x ULN persists.1

Please refer to the NILEMDO® SmPC prior to prescribing.1

Discover more

Lipid management

Explore the role of lipid-lowering therapies in CV risk reduction for eligible patients

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Guidance

How bempedoic acid could help your eligible patients meet their LDL-C treatment targets

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Mechanism of Action

Discover how bempedoic acid works to complement other lipid-lowering therapies

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Efficacy

Examine the results of bempedoic acid from controlled clinical studies

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Safety profile

Review adverse reactions, contraindications and special warnings of bempedoic acid

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Resources and support

Find downloads, videos and implementation support tools for HCPs

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Latest expert opinions

References

  1. NILEMDO® Summary of Product Characteristics.
  2. NUSTENDI® Summary of Product Characteristics.
  3. Nissen SE, et al. N Engl J Med. 2023;338(15):1353–1364.
  4. National Institute for Health and Care Excellence. Bempedoic acid with ezetimibe for treating primary hypercholesterolaemia or mixed dyslipidaemia [TA694]. Available at: https://www.nice.org.uk/guidance/TA694 Accessed: February 2025.

Abbreviations

ASCVD, atherosclerotic cardiovascular disease; CV, cardiovascular; HCP, healthcare professional; LDL-C, low-density lipoprotein cholesterol; SmPC, Summary of Product Characteristics; ULN, upper limit of normal.

Job code: UK/BIL/11/24/0004|Date of preparation: February 2025

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