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*For study results with respect to effects on LDL-C, CV events and populations studied see section 5.1 of the relevant SmPC.1,2
CV risk reduction estimation for ezetimibe in primary prevention patients has not been established. Evidence for the use of NUSTENDI® in patients at high risk of ASCVD is only available for the lipid-lowering effect (see section 5.1 of the NUSTENDI® SmPC).2
Concomitant use with simvastatin >40 mg daily is contraindicated; please refer to the SmPC for more information.2
For patients taking a bile acid sequestrant concomitantly, dosing of NUSTENDI® should occur either at least 2 hours before or at least 4 hours after administration of a bile acid sequestrant.2
Liver function tests should be performed at initiation of NUSTENDI® therapy and treatment with NUSTENDI® should be discontinued if an increase in transaminases >3x ULN persists.2
Please refer to the NUSTENDI® SmPC prior to prescribing.2
Concomitant use with simvastatin >40 mg daily is contraindicated; please refer to the SmPC for more information.1
Liver function tests should be performed at initiation of NILEMDO® therapy and treatment with NILEMDO® should be discontinued if an increase in transaminases >3x ULN persists.1
Please refer to the NILEMDO® SmPC prior to prescribing.1
References
Abbreviations
ASCVD, atherosclerotic cardiovascular disease; CV, cardiovascular; HCP, healthcare professional; LDL-C, low-density lipoprotein cholesterol; SmPC, Summary of Product Characteristics; ULN, upper limit of normal.
Job code: UK/BIL/11/24/0004|Date of preparation: February 2025
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